Vaccines for the Prevention of Pneumococcal Disease.

I caused by Streptococcus p n e u m o n i a e r e m a i n a m a j o r public health problem worldwide. Due to large serotype diversity i n p n e u m o c o c c u s , v a c c i n e s that induce antibody responses against multiple capsular antigens h a ve b e e n d e ve l o p e d . At t h e moment, there are two licensed anti-pneumococcal vaccines for possible use in elderly people: the classical 23-valent pneumococcal polysaccharide vaccine (PPV23)1 and the 13-valent pneumococcal conjugate vaccine (PCV13), which substituted the PCV7 in children and has been licensed for use in preventing invasive pneumococcal disease (IPD) and pneumonia in people over 50 years old.2,3